ackground : The genetic factors involved in the etiology of human leukmia have been discussed including the occurrence of leukemia in twins, leukmia in relatives of leukemic patients, the relation of genotypes and phenotypes to leukemia,
and
the
complication of
leukemia in various congenital diseases associated with chromosomal abnormalties and/or
immunodeficiencies, but there are many problems that remain to be clarified.
Case : We experienced 2 cases of acute myelogenous leukemia within a family. Young
brother and elderly sister whose father had been died of acute leukemia was diagnosed as
AML (M4) and AML (M1), respectively. The sister aged 19 presented with dizziness and
dyspnea was given Ara-c and Daunorubicin chemotheraphy but expired without response.
Young brother aged 17 presented with fever and epistaxis was responded well to the same
regimen chemotheraphy, in remission. But his leukemia was relapsed despite of following 2
cycles of consolidation chemotherapy, and died of 7 months after treatment. Known
leukemogenic factor such as, radiation, drug, chemical exposure was excluded in these patient.
Conclusion : Although about 130 cases of familial leukemia has been described to date in
other countries, no case has been reported in Korea. So we report this case with brief review
of the literiture.
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